BIOPROCESSING

04.06

Bioproduction Flocculation
starts with specification.

Chitosan’s positive charge can aggregate negatively charged cells and suspended solids into separable flocs.

Bioprocess researcher working with laboratory separation equipment
BIOPRODUCTION · SEPARATION SCIENCE
PHARMACEUTICAL DEVELOPMENT PROGRAMPHARMA

01 · THE CUSTOMER PROBLEM

Bioprocessors need to recover cells or biomass without overloading downstream filtration, adding persistent flocculants or accepting poor separation economics.

Charge-controlled chitosan can aggregate cells and suspended solids into recoverable flocs while dose, pH and removal are optimized around the actual broth.

Chitosan’s positive charge can aggregate negatively charged cells and suspended solids into separable flocs.

02 · RECOMMENDED STARTING POINT

Start with the material designed for the decision.

MYKITO PLATFORMBioFoundry
RECOMMENDED SAMPLEA charge-density screening set with a bench-scale jar-test protocol.

As a bio-based process aid, chitosan can simplify clarification and biomass recovery while giving process developers control over dose, molecular specification and removal validation.

01

Without the shell

Controlled fungal sourcing supports a traceable, non-animal supply strategy.

02

Specification engineered

MW, DDA, purity, charge density and format are selected around the target result.

03

Application ready

Powder is only the starting point; Mykito also develops films, fibers, gels, coatings and formulations.

04

One technical partner

Material selection, formulation support and the validation plan are connected from the first sample.

03 · PERFORMANCE TARGETS

Build toward outcomes a buyer can measure.

01

Cell aggregation

Charge neutralization and polymer bridging bring suspended cells together into larger, recoverable flocs.

02

Biomass harvesting

Chitosan can support sedimentation, filtration or flotation in microbial and algal production systems.

03

Clarification support

Flocculation can reduce suspended solids entering downstream filtration and separation operations.

04

Process integration

Dose, pH and mixing can be optimized around the organism, broth chemistry and recovery method.

04 · GO / NO-GO CRITERIA

Define the evidence before testing begins.

The first program is designed around three decision-making outputs—not an open-ended material trial.

01

Dose-to-recovery curve

02

Settling, filtration or flotation improvement

03

Residual removal and cost per processed volume

Charge densityMW + DDADose responsepH windowResidual-removal validation

05 · FROM SAMPLE TO DECISION

A practical application program,
not a bag of powder.

01

Define

Agree on the function, baseline, constraints and measurable success criteria.

02

Screen

Select the MW, DDA, purity, dose and physical format that fit the application.

03

Validate

Test the winning system in the finished formulation, device, process or use environment.

AVAILABLE FORMATS
Low-MW powderReady-to-dose liquidCustom process blend

Recommended first request: A charge-density screening set with a bench-scale jar-test protocol.

Start the Sample Brief

06 · WHY CHITOSAN

Cationic complexation + matrix control

Protonated amino groups can interact with selected anionic actives, polymers and biological surfaces. MW, DDA, crosslinking and architecture then provide levers for adhesion, protection and release.

FORMULATION WINDOW

There is no universal concentration. Grade and dose are screened against pH, interacting ingredients, process conditions and the target performance profile.

QUALIFICATION

Route-specific purity, residuals, compatibility, stability and regulatory suitability are established for the finished system.

DEVELOPMENT CONTEXT

These application pathways describe material-development potential, not a claim that any final device, drug or therapy is approved. Biocompatibility, safety, performance, sterilization and regulatory requirements are established for the finished product and its intended use.

START AN APPLICATION PROGRAM

Move from material potential
to a defined program.

Tell us what performance, purity and format your application needs. We will help identify the right Mykito platform and a practical next step.